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71.
Ryuichiro Mizuno Teruyuki Kawabata Yuichi Sutoh Yuzo Nishida Shigeru Okada 《Biometals》2006,19(6):675-683
Oxidative renal tubular injuries and carcinogenesis induced by FeIII-nitrilotriacetate (NTA) and FeIII–ethylenediamine-N,N′-diacetate (EDDA) have been reported in rodent kidneys, but the identity of iron coordination structure essential for renal carcinogenesis, remains to be clarified. We compared renal tubular injuries caused by various low molecular weight aminocarboxylate type chelators with injuries due to NTA and EDDA. We found that FeIII-iminodiacetate (IDA), a novel iron-chelator, induced acute tubular injuries and lipid peroxidation to the same extent. We also prepared FeIII-IDA solutions at different pHs, and studied resultant oxidative injuries and physicochemical properties. The use of FeIII-IDA at pH 5.2, 6.2, and 7.2 resulted in renal tubular necrosis and apoptotic cell death, but neither tubular necrosis nor apoptosis was observed at pH 8.2. Spectrophotometric data suggested that FeIII-IDA had the same dimer structure from pH 6.2 to 7.2 as FeIII-NTA; but at a higher pH, iron polymerized and formed clusters. FeIII-IDA was crystallized, and this was confirmed by X-ray analysis and magnetic susceptibility measurements. These data indicated that FeIII-IDA possessed a linear μ-oxo bridged dinuclear iron (III) around neutral pH. 相似文献
72.
Shigeru Yamada Eiichiro Uchimura Takanori Ueda Fukumi Iguchi Yutaka Akiyama Satoshi Fujita Masato Miyake Jun Miyake 《NanoBioTechnology》2006,2(3-4):95-100
We propose a simple procedure for the identification and quantitative analysis of neurite outgrowth in neuronal cell lines
that were uniformly differentiated. Upon stimulation most neuronal cell lines extend neurites in the differentiation process,
resulting, according to our observation, in the increase of cell surface area. This increase is dependent on the length and
the number of extended neurites. Furthermore, we use this method for the phenotype analysis of cell array experiments to perform
large-scale functional evaluation of genes involved in the neurite outgrowth during neuronal differentiation. 相似文献
73.
Hydrobiologia - To clarify the effect of paternal life-history form and egg size on offspring life-history traits (e.g., growth and maturation) in masu salmon (Oncorhynchus masou), we studied an... 相似文献
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75.
Yoshitaka Kaitsu Kiminori Shimizu Eiji Tanaka Satoshi Shimano Shigeru Uchiyama Chihiro Tanaka Noriko Kinjo 《Mycological Progress》2013,12(4):755-761
Ophiocordyceps sessilis, a new species of Ophiocordycipitaceae, Hypocreales, was found on Camponotus obscuripes ants, where the ants were primarily infected by another close relative, O. pulvinata. Morphological observation clearly indicated that O. sessilis and O. pulvinata are distinct species. Ophiocordyceps sessilis exhibited superficial development of perithecia and ascospore disarticulation into part-spores, not known in O. pulvinata. Nucleotide sequence data suggested that O. sessilis belongs in Ophiocordyceps, Ophiocordycipitaceae. Molecular data also indicated that O. sessilis is a close relative of O. cuboidea, O. prolifica, O. paracuboidea, and O. ryogamiensis, which are all known to produce part-spores. Since O. sessilis is always associated with ants infected by O. pulvinata, O. sessilis may be a hyperparasite of O. pulvinata. 相似文献
76.
The female silkworm, Bombyx mori, rapidly accumulates two storage proteins, that are synthesized by the fat body, in the haemolymph during the feeding stage of the last-larval instar, and then sequesters them from the haemolymph into fat body during the larval-pupal transformation.The rapid synthesis and uptake of storage proteins by the fat body are shown to be induced by allatectomy in the early-penultimate larval instar. A juvenile hormone analogue, methoprene, is highly effective in inhibiting the allatectomy-induced synthesis, and, in a higher dosage, further blocks the uptake. Allatectomy in the late-penultimate larval instar shortly before moulting does not enhance the storage protein synthesis, but causes the uptake to occur two days earlier in the last-larval instar. Injection of 20-hydroxyecdysone is not stimulatory for synthesis of the proteins, but is effective to induce their uptake. Starvation during the early last-larval instar completely blocks the synthesis.From these results, it is suggested that storage protein synthesis is induced in the absence of juvenile hormone by some supplementary stimulus, possibly the supply of nutrient after feeding, and uptake is induced by ecdysteroids after a decline in the juvenile hormone level. 相似文献
77.
The major glycoproteins of horse and swine erythrocyte membranes were isolated and examined chemically and immunologically. The major glycoprotein of horse erythrocyte membranes had a molecular weight of 33 000 and consisted of 46.2% protein and 53.8% carbohydrate, of which 9.4% was hexose, 10.1% hexosamine and 33.7% sialic acid. This glycoprotein was associated with activity for the infectious mononucleosis heterophile antigen.There were two different major glycoproteins in swine erythrocyte membranes. One major glycoprotein had a molecular weight of 46 200 and consisted of 34.2% protein and 65.8% carbohydrate, of which 18% was hexose, 19% hexosamine and 27.2% sialic acid. This glycoprotein had phytohemagglutinin (Phaseolus vulgaris) binding activity. The other glycoprotein had a molecular weight of 29 000 and consisted of 50.4% protein and 49.6% carbohydrate, of which 6.4% was hexose, 7.0% hexosamine and 36.3% sialic acid. This glycoprotein had weak or absent phytohemagglutinin binding activity. 相似文献
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80.
Koji Sugano Toru Okuyama Shinsuke Iida Hirokazu Komatsu Takashi Ishida Shigeru Kusumoto Megumi Uchida Tomohiro Nakaguchi Yosuke Kubota Yoshinori Ito Kazuhisa Takahashi Tatsuo Akechi 《PloS one》2015,10(8)